SYN®-AKE (Viper Venom as we like to call it) is a new anti-wrinkle active compound based on a synthetic tripeptide that mimics the affect of Waglerin 1, a peptide that is found in the venom of the Temple Viper, Tropidolaemus wagleri. Used for its excellent anti-wrinkle active compound which smooths mimic wrinkles in a short period of time.
NOTE: this serum will give an immediate Botox-like effect but it is also cumulative. This product can take 60 - 90 days to show this effect, depending on other product used. This product should be used ONLY for spot treatments, i.e. laugh lines, forehead, neck, crow's feet, etc
Method of Application Our Viper Venom Serum is meant to be applied twice daily, not to the wrinkle or line itself, instead to the muscles that make the wrinkles. (Please see the Facial Chart in the photos) You can also make faces in the mirror to see where the muscles are. It’s fun and you'll learn something at the same time. ;)
Directions: Apply 1 -2 drops to the muscle area that creates the wrinkle or line that you would like to eliminate.
Shelf Life and Storage Information for Our Products and Ingredients
Finished Products - generally don't need to be refrigerated as they are preserved, but you can refrigerate them to extend their shelf life. The shelf life for most products is 9-12 months. Vitamin C Serum(s) and VitaResurface products should continually be refrigerated to extend their shelf life. Sample Sizes - do have a shorter shelf life (generally 3-6 months), and items in jars can dry up quicker than this if the lid is not tightened well enough (Vitamin C Serums - use within 90 days).
Please keep your products out of humidity, heat, direct light and in a dark cabinet when possible:
Exfoliating Acid - products have a shelf life of 9-12 months. The only things we don't suggest refrigerating are the Mandelic Acid Serums or Salicylic Acid Serums, as they can crystallize in the refrigerator. If this happens, you can set the product into a hot water bath to see if the crystals will dissolve.
Additional Items That Require Refrigeration and/or Kept in the Dark:
Hydrosols and Distillates - remove 1 ounce of hydrosol and add it into a separate,sterilized spray bottle and spritzer. Keep the larger bottle in the refrigerator. Carrier and Exotic Oils - generally, you can refrigerate all carrier oils, although some very rich oils will solidify. This is fine. All you have to do is take it out, warm it up at room temperature and it should liquefy. If not, set the bottle in a hot water bath and occasionally shake the bottle, which will hopefully turn into a liquid. There are some oils with a super long shelf life, like Coconut Cream and Jojoba Oil.
Refrigeration is not necessary, but it surely won't hurt:
Essential Oils - essential oils are best stored in a cool, dark place. Co2 Extracts - these should continually be refrigerated. Butters - we suggest refrigerating our "skincare" butters. You can remove what you need and keep the rest in the fridge. Clays - keep in a dry, dark place. Shelf life is at least 2 years. Herbs - all herbs (whole or ground) should be kept in a dark, cool and dry location. Herbal (liquid) Extracts - these are created using alcohol. The alcohol pulls the constituents (properties) from each herbs - root, trunk, leaves, and flowers. They have a shelf life of 3-5 years. They can be kept in the refrigerator or a dark place. Other Raw Ingredients - i.e., Sodium PCA, Honeyquat, Oat Beta Glucan, etc. will all have a different shelf life.
Hyaluronic Acid hydrating, can hold up to 1,000 times it's weight in water
Syn®-Ake 5%
SYN®-AKE – Age Killing Effect. • Antagonist of the muscle nicotinic acetylcholine receptor (mnAChR) • Blocks Na+ uptake at the post-synaptic membrane • Inhibits muscle contractions
SYN®-AKE is a new anti-wrinkle active compound based on a synthetic tripeptide that mimics the effect of Waglerin 1, a peptide that is found in the venom of the Temple Viper, Tropidolaemus wagleri. PENTAPHARM *(Syn-ake's manufacturer) has developed, over the past 30 years, a unique approach for the breeding and housing of venomous snakes and particularly the Brazilian Lance Adder Bothrops moojeni whose venom is used for therapeutic (anticoagulants, haemostatics) and diagnostic products. Currently, some 10, 000 specimens of this snake species are bred and housed at PENTAPHARM DO BRASIL, making PENTAPHARM the largest snake breeder and keeper in the world. The long experience of PENTAPHARM in snake venom research has made possible the investigation of venom’ peptides for cosmetic applications. A special focus has been the investigation of the Temple Viper’s venom.
SYN®-AKE acts in a manner similar to that of Waglerin 1 which acts at the post-synaptic membrane. The peptide is an antagonist of the muscular nicotinic acetylcholine membrane’s receptor (mnAChR). As the muscular nicotinic ACh receptors are blocked, the ion canal remains closed. There is no uptake of Na+ and the muscles stay relaxed. Source: McArdle, JJ, T L Lentz, V Witzemann, H Schwarz, SA Weinstein& JJ Schmidt. 1999. Waglerin-1 selectively blocks the epsilon form of the muscle nicotinic acetylcholine receptor. J. Pharmacol. Exp. Therap.
Function:
• SYN®-AKE is an excellent anti-wrinkle active compound with a snake venom-like mode of activity. • SYN®-AKE smoothes mimic wrinkles in a short period.
Cosmetic applications: • Age killing effect particularly effective against expression lines • Intensive anti-wrinkles care
Efficacy Tests- in vitro tests: The efficacy of the SYN®-AKE tripeptide (at a concentration of 0.5mM) has been demonstrated in vitro by measuring the frequency of contraction of the innervated muscle cells as a function of the incubation time.
SYN®-AKE peptide reduces muscle cell contraction and its action is reversible.
In vivo tests:
The measurement of the smoothing and anti-wrinkle effect of SYN®-AKE (4%) was compared to a placebo. A cream was applied to the forehead twice daily during 28 days.
SYN®-AKE – Age Killing Effect.
The smoothing effect (Ra) was measured on 80% of the volunteers and the anti-wrinkle effect (Rz, Rt) measured on 73% of the volunteers.
Results showed up to -52% of wrinkle size after 28 days application!
Leucidal SF(lactobacillus) - natural, probiotic based preservative
This is my favorite product I have tried. Next to one other. It’s costly but lasts a long time. I truly can’t live without this one. It helps control contracting muscles. Great for people with bad vision and people who work on a computer all day. I genuinely love this product. And can’t recommend it enough.
Thank you for reviewing this! :)
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Andrea
Giving it a try
I decided to try the Viper Venom because it uses one of the top rated "botox in a bottle" active ingredients, Syn-ake, and at the recommended concentration, 5%, according to my research. I've had no adverse effects, but neither have I seen any positive effects yet on my sixty-eight year old wrinkles. However, I've only been using it for three weeks. So, I still have hope.
Hi Andrea!
This can take up to 60 - 90 days to take effect, depending on what else is being used in the routine. Also, make sure you're applying it to the areas on your skin according to the chart on the site! You want to target the muscle areas. Also make sure to apply to dry/clean skin! :)
This isn't meant for all over or general wrinkles. Drop us an email and we can look at the rest of your routine, to see if anything could be interfering! :)
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Anonymous
The Viper Venom and DMAE are fantastic..
The Viper Venom and DMAE are fantastic, they really do what they're said to do. Great stuff, Markey, and I'm so glad you're out there, sourcing these finds for us all.
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Megan Burns
Slight headache after 2 weeks
I ordered this product to improve my forehead wrinkles. I'm in my late 20s, but as a white, expressive individual living in a desert, my forehead was already looking well beyond my years. I use two drops on my forehead and between my eyes twice a day. It is a clear, watery consistency that dries down quickly. I've also been using a bakuchiol (retinol alternative) daily and AHAs 2-3 times per week. I've noticed significant improvement in my forehead lines in the ~5 weeks of using this serum. I did notice an odd headache right where the serum is applied about two weeks in, although that only lasted a day or two. It makes sense considering it has a botox-like effect. I purchased the .25oz bottle, and I worried I would use it up before noticing results. I've been pleasantly surprised that I have only used half of the bottle with twice daily use. I don't know how much of my results were from this serum and how much were from my other products. I may try to wait a week between finishing this bottle and purchasing a replacement to see if this was significantly contributing to my results.
