Viper Venom 5% Serum


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Synake (Viper Venom as we like to call it) is a new anti-wrinkle active compound based on a synthetic tripeptide that mimics the affect of Waglerin 1, a peptide that is found in the venom of the Temple Viper, Tropidolaemus wagleri. Used for its excellent anti-wrinkle active compound which smooths mimic wrinkles in a short period of time.

Viper Venom Information Sheet for Printing

NOTE: this serum will give an immediate Botox-like effect but it is also cumulative. This product can take 60 - 90 days to show this effect, depending on other product used. This product should be used ONLY for spot treatments, i.e. laugh lines, forehead, neck, crow's feet, etc 

Method of Application
Our Viper Venom Serum is meant to be applied twice daily, not to the wrinkle or line itself, instead to the muscles that make the wrinkles. (Please see the Facial Chart in the photos) You can also make faces in the mirror to see where the muscles are. It’s fun and you'll learn something at the same time. ;)
Directions: Apply 1 -2 drops to the muscle area that creates the wrinkle or line that you would like to eliminate.

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Shelf Life and Storage Information for Products and Ingredients

Finished products generally don't need to be refrigerated as they are preserved, but you can refrigerate them to extend shelf life. Shelf life is 9 - 12 months

Sample sizes do have a shorter shelf life (generally 3-6 months and items in jars can dry up quicker than this if the lid is not tightened well enough (except our vitamin C serums - use within 90 days).

Please try to keep out of high humidity or heat if possible! Store out of direct light and in dark cabinet if possible also!

Exfoliating Acid products will last 1 year.

The only thing we don't suggest refrigerating is the mandelic or salicylic acid serums as those can crystallize in the refrigerator and not go back to their normal state even if you warm them up.

Additional Items Requiring Refrigeration

Hydrosols - Take out 1/2 oz to 1 oz in a separate spray bottle from your original container and keep the larger bottle in the refrigerator!

Carrier Oils - Generally you can refrigerate ALL carrier oils, they will solidify in some cases. This is FINE all you have to do is take it out warm it up at room temp and it will be liquid again!
There are some oils that have a super long shelf life like coconut oil for instance! That does not need to be refrigerated, but it cannot hurt it either!

Essential Oils - Essential oils are best stored in a cool dark place.

Co2 Oils - These should always be refrigerated.

Butters - We suggest refrigerating our skincare butters. You can take out what you need and keep the rest in the fridge.

Essential oils - These can be refrigerated to increase their shelf life!

Clays - Keep in a dry, dark place (shelf life is at least 2 years)

Herbs - (whole or ground) These should last a good year at least - Keep in a dark, cool and dry location.

Herbal Extracts - [powder] Keep these also in a dark, DRY place. You can keep in the fridge, but make sure the seal is on very tight so you don't get moisture in. [1 year at least].

Herbal Extracts - [liquid] These can be kept in the refrigerator (or a dark DRY place] [3 years at least]

Other Various Raw Ingredients - i.e. Sodium PCA, Honeyquat, Iat Beta Glucan etc will all have a different shelf life (we are working on adding this to the ingredient pages.

Hyaluronic Acid hydrating, can hold up to 1,000 times it's weight in water

Syn®-Ake 5% 

SYN®-AKE – Age Killing Effect. 
• Antagonist of the muscle nicotinic acetylcholine receptor (mnAChR)
• Blocks Na+ uptake at the post-synaptic membrane
• Inhibits muscle contractions

SYN®-AKE is a new anti-wrinkle active compound based on a synthetic tripeptide that mimics the effect of Waglerin 1, a peptide that is found in the venom of the Temple Viper, Tropidolaemus wagleri. PENTAPHARM *(Syn-ake's manufacturer) has developed, over the past 30 years, a unique approach for the breeding and housing of venomous snakes and particularly the Brazilian Lance Adder Bothrops moojeni whose venom is used for therapeutic (anticoagulants, haemostatics) and diagnostic products. Currently, some 10, 000 specimens of this snake species are bred and housed at PENTAPHARM DO BRASIL, making PENTAPHARM the largest snake breeder and keeper in the world. The long experience of PENTAPHARM in snake venom research has made possible the investigation of venom’ peptides for cosmetic applications. A special focus has been the investigation of the Temple Viper’s venom.

SYN®-AKE acts in a manner similar to that of Waglerin 1 which acts at the post-synaptic membrane. The peptide is an antagonist of the muscular nicotinic acetylcholine membrane’s receptor (mnAChR). As the muscular nicotinic ACh receptors are blocked, the ion canal remains closed. There is no uptake of Na+ and the muscles stay relaxed. Source: McArdle, JJ, T L Lentz, V Witzemann, H Schwarz, SA Weinstein& JJ Schmidt. 1999. Waglerin-1 selectively blocks the epsilon form of the muscle nicotinic acetylcholine receptor. J. Pharmacol. Exp. Therap. 


• SYN®-AKE is an excellent anti-wrinkle active compound with a snake venom-like mode of activity.
• SYN®-AKE smoothes mimic wrinkles in a short period.

Cosmetic applications:
• Age killing effect particularly effective against expression lines
• Intensive anti-wrinkles care

INCI Name:
Glycerine, Water, Dipeptide Diaminobutyroyl Benzylamide Diacetate

Efficacy Tests- in vitro tests:
The efficacy of the SYN®-AKE tripeptide (at a concentration of 0.5mM) has been demonstrated in vitro by measuring the frequency of contraction of the innervated muscle cells as a function of the incubation time.

SYN®-AKE peptide reduces muscle cell contraction and its action is reversible.

In vivo tests:

The measurement of the smoothing and anti-wrinkle effect of SYN®-AKE (4%) was compared to a placebo.
A cream was applied to the forehead twice daily during 28 days.

SYN®-AKE – Age Killing Effect.

The smoothing effect (Ra) was measured on 80% of the volunteers and the anti-wrinkle effect (Rz, Rt) measured on 73% of the volunteers.

 Results showed up to -52% of wrinkle size after
28 days application!