Sometimes your skin is not dry, not oily, not even reactive... it is simply overwhelmed. It stops responding the way it used to. It looks a little more tired, a little less even, a little harder to settle. This is where Revitalize Your Skin Serum with Neurophroline™ begins.
This silky, lightweight serum was created for skin that is carrying the effects of daily stress. Not to force change, but to gently support a calmer, more balanced appearance. Skin is left looking more even, more rested, and more at ease.
At the center of this formula is Neurophroline™, a wild indigo seed extract chosen specifically for its ability to help reduce the visible effects of stress on the skin by reducing cortisol production locally in the skin cell. Rather than pushing the skin harder, it works in a quieter way, supporting a more refreshed, balanced complexion over time.
We paired it with Oat Beta Glucan, Thermo-stressine, Superoxide Dismutase, and other carefully chosen ingredients that help comfort the skin and defend against visible environmental strain.
This is not about pushing the skin harder. It is about helping it find its way back to balance.
Key Benefits
➜ Helps reduce the visible effects of daily skin stress
➜ Supports a calmer, more balanced-looking complexion
➜ Helps improve the appearance of uneven tone and fatigue
➜ Lightweight hydration without heaviness or buildup
➜ Supports skin exposed to environmental and emotional stress
Why It Feels Different
When skin is under ongoing stress, it does not always react loudly. Instead, it can begin to look duller, feel less comfortable, or lose some of its natural balance. This formula was designed with that in mind.
Neurophroline™ helps target the visible effects of stress on the skin, while Oat Beta Glucan helps soothe and support the skin barrier. Thermo-stressine helps support skin exposed to changing environmental conditions, and Superoxide Dismutase offers antioxidant support to help defend against visible oxidative stress.
Together, these ingredients create a serum that feels light, calm, and supportive, especially for skin that needs less pressure and more consistency.
Method of Application
Apply a small amount to clean skin after your water-based layers and before heavier serums, oils, or creams. Gently smooth over the face, focusing on areas that appear tired, uneven, or stress-worn. Use morning, evening, or both.
Featured Ingredients
➜Neurophroline™ – is a wild indigo seed extract that helps stressed skin calm down. Skin cells can produce cortisol locally in response to stress, and when cortisol stays elevated it can show up as redness, dullness, dehydration, and a more reactive barrier. Neurophroline is designed to help reduce cortisol production in skin cells while also encouraging the release of a calming neuropeptide (beta-endorphin), which supports a more balanced, refreshed-looking complexion over time.
➜Oat Beta Glucan – Helps soothe and support the skin barrier, contributing to a calmer feel.
➜Thermo-stressine – Helps support skin exposed to environmental stress and fluctuating conditions.
➜Superoxide Dismutase (S.O.D.) – An antioxidant enzyme that helps defend against visible oxidative stress.
Technical Notes
Neurophroline™ is derived from Wild Indigo (Tephrosia purpurea). This specialized extract contains naturally occurring sugars, including stachyose and ciceritol, and has been studied for its ability to help visibly improve skin tone and reduce the appearance of stress-related skin fatigue.
Shelf Life and Storage Information for Our Products and Ingredients
Finished Products - generally don't need to be refrigerated as they are preserved, but you can refrigerate them to extend their shelf life. The shelf life for most products is 9-12 months. Vitamin C Serum(s) and VitaResurface products should continually be refrigerated to extend their shelf life. Sample Sizes - do have a shorter shelf life (generally 3-6 months), and items in jars can dry up quicker than this if the lid is not tightened well enough (Vitamin C Serums - use within 90 days).
Please Keep Your Products Out of Humidity, Heat, Direct Light and in a Dark Cabinet When Possible
Exfoliating Acid - products have a shelf life of 9-12 months. The only things we don't suggest refrigerating are the Mandelic Acid Serums or Salicylic Acid Serums, as they can crystallize in the refrigerator. If this happens, you can set the product into a hot water bath to see if the crystals will dissolve.
Additional Items That Require Refrigeration and/or Kept in the Dark
Hydrosols and Distillates - remove 1 ounce of hydrosol and add it to a separate, sterilized spray bottle and spritzer. Keep the larger bottle in the refrigerator. Carrier and Exotic Oils - generally refrigerate all carrier oils, although some very rich oils will solidify. This is fine. All you have to do is take the oil out, warm it up at room temperature, and it should liquefy. If not, set the bottle in a hot water bath and occasionally shake the bottle, which will hopefully turn into a liquid. Some oils, like coconut cream and jojoba oil, have a super long shelf life.
Refrigeration of The Following Ingredients is Not Necessary, But it Won't hurt
Essential Oils - essential oils are best stored in a cool, dark place. Co2 Extracts - these should continually be refrigerated. Butters - we suggest refrigerating our "skincare" butters. You can remove what you need and keep the rest in the fridge. Clays - keep in a dry, dark place. Shelf life is at least 2 years. Herbs All herbs <i>(whole or ground)</i> should be kept in a dark, cool, and dry location. Herbal (liquid) Extracts are created using grain alcohol. The alcohol pulls the constituents (properties) from each herb, root, trunk, leaf, and flower. They have a shelf life of 3-5 years. They can be stored in the refrigerator or a dark, dry place. Other Raw Ingredients - such as Sodium PCA, Honeyquat, Oat Beta Glucan, etc., will all have different shelf lives.
Spring Water hydrating and helps prepare the skin to accept active ingredients Liposomes (phospholipids) penetration enhancer and extremely hydrating Leucidal SF (Lactobacillis Ferment) gentle preservative without parabens or formaldehyde releasers Neurophroline this exclusive extract has demonstrated its unique biological capabilities to break down the cortisol production by skin cells, activate the release of a natural calming neuropeptide acting to reduce redness, and enhance the overall appearance of the skin. Thermostressine® (tetrapeptide)this tetrapeptide increases the skin's tolerance to jet-lag and other daily lifestyle stresses. The proteotoxic stress is well controlled and damage prevented. Oat Beta Glucans are being studied for their potential immunomodulatory effects, anti-tumor properties, and stimulation of collagen deposition. Oat Beta Glucans have amazing healing properties.
Hyaluronic Acid (high molecular weight)Hyaluronic acid is a natural polysaccharide (large sugar molecule) that occurs in various tissues (skin, synovial fluids of joints, connective tissues).
Hyaluronic Acid(super low molecular weight)hyaluronic acid (sodium hyaluronate) is a natural polysaccharide (sugar) that occurs in body tissues including the skin providing hydration, stability, lubrication. This super low-molecular-weight form is made by enzymatically cleaving high-molecular weight hyaluronic acid into small fragments.
Dehydroxanthan Gumis obtained from fermented polysaccharides.This ia natural thickener. AllTrans ResveratrolAllTrans-resveratrol is a naturally occurring compound in certain plants, particularly grapes and red wine. It has been of interest in skincare and cosmetics due to its potential antioxidant and anti-aging properties. When applied topically to the skin, trans-resveratrol can exhibit several beneficial properties like antioxidant protection, anti-inflammatory, skin brightening, UV protection, collagen production and really keeps the skin hydrated. Apple Polyphenols are natural compounds found in apples, particularly in the skin and seeds of the fruit. They are a type of phytochemical, which means they are plant derived. Apple polyphenols, when used in topical applications, offer antioxidants, UV Protection, anti-inflammatory effects, they improve skin hydration while boosting collagen production. Yes, they are this good. Sclerotium Gum is a naturally derived, gel-like polysaccharide (sugar-based) thickener. Super Oxide Dismutase (S.O.D.) the highly purified superoxide dismutase made from Saccharomyces cerevisiae for skin care products. Offering anti-aging and skin-whitening properties while providing potent antioxidant effects inhibiting free radical formation.
This serum is a lovely tool in fighting signs of aging cause by lifes little stressors :)
Thank you, Erika.
You are adorable. We are always happy to hear when a product shows the results
one is hoping for.
Thank you for the video!
Markey ˚⊱⊰˚
A
Anonymous
Love it!
I love this product & so does my skin! For me, that is a huge blessing.
Hi Elayne!
Thank you for mentioning this product. It doesn't get enough ❤️.
Wishing you the best, as always, with your skincare journey.
Markey and Your GoW Crew of Lovlies.
˖˳·˖ ִֶָ ⋆͙⋆ ִֶָ˖·˳˖ ִֶָ
R
Rachel
Staple!!
Love love all GoW products I've tried, but this one was particularly interesting because of the Cortisol component! My skin has been a challenge the last 10 years and a lot of that was likely due to stress and hormones. In the last few years, things seemed to have leveled out but I still need support of course. I really do believe in a week or so I saw results from this serum. My skin is happy and hydrated! About to reorder my 2nd bottle :)
This is such a thoughtful review, and we're SOO happy for your results! Thank you so much :)
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Frances S
Amazing product
I used this serum for the first time this week and I swear my skin immediately felt immediate relief. My skin actually feels satiated when I apply the serum. It is more even and glowing. I’m obsessed and hope this product is restocked asap. Thank you garden of wisdom!!!
Frances! I couldn't agree more! We tested this for awhile before releasing it and this product really is a game changer especially for those of us who find it more challenging to keep our skin hydrated and beautiful.
Thank you for the wonderful review, we always appreciate reviews.
Markey :-D
I have suffered from all forms of rosacea and have improved dramatically since using this and
I have suffered from all forms of rosacea and have improved dramatically since using this and other clean and simple GOW products. I feel that the manuka honey serum is an essential base to the layering of serums I do.
Manuka Honey Hyaluronic Acid Serum
KIM KELLY
Thanakha Blemish Clearing Tonic
Garden of Wisdom Thanakha Blemish Clearing Tonic really works!! I don’t know what the magic is in the formula, but it gets overnight results and clears up blemishes faster than anything I’ve ever used. Terrific product!!
Garden Of Wisdom Skincare
Laura
Absolute best thing for my white dry flyaway hair
Absolute best thing for my white dry flyaway hair. 1/2 tsp MCT Oil heated with 1/4 tsp Cetyl Alcohol in a baby food jar in water in a leg wax warmer. When melted I add 1 tsp Distilled Water. I let cool in the warmer & apply to hair.
Cetyl Alcohol NF
Anonymous
This is my all time favorite body oil
This is my all time favorite body oil. Feels very luxurious.
Bakuchiol Body Bliss Oil (Body Only)
Anonymous
Perfect for hot summer days when you have to wash your hair almost every day
Perfect for hot summer days when you have to wash your hair almost every day. Gentle and clean. Makes hair feel so soft.
Locks of Lovely Shampoo (Unscented): Pure, Nourishing, and Gentle Care for Your Hair
Caroline Moyer
Good for emerging blemishes
I like this stuff! My blemishes are usually just tiny irritated white heads or bumps with nothing in them. If I put this on at night, things are much calmer in the morning. It even seems to have a minimizing effect on the few deep painful cystic guys I get, so they end up fading away rather than coming to the surface full of rage. And so far I haven't had any irritation (and I have very sensitive skin). I put this on after my last oil stage, after things have dried down a bit. I feel like that works best since I use it as a spot treatment, and putting it on under other stuff seems like it would just spread it around.
Sulfur Clearing Serum
Marian Jamieson
This is the best one!
This is the best one! My skin is sensitive to unusual things and the leucidal hyaluronic acid serums don't give me any issue. I prefer the honey to the regular because it helps my acne. I had to order the regular/pure HA serum last time and I definitely noticed breakouts lasting longer. Honey comb is the way to go!
Honey Comb Hyaluronic Acid Serum (Leucidal)
Amber A
Gentle non irritating niacinimide serum
Gentle, non irritating niacinimide serum. Another wonderful light and layerable product from GoW. I like how this serum plays well with my other products and it’s not sticky. This has been very helpful for my stepson’s oily teenage skin as well. Thank you!
B3/B5 Duality Facial Serum – Hydrating Vitamin B3 and B5 Serum for Balanced, Healthy Skin
Anonymous
The perfect cleanser with no harsh ingredients
The perfect cleanser with no harsh ingredients. I have been using this cleanser for years and it is the best!
Creamy Cleanser
TONI B.
Awesome progeline peptide repair serum
I have this product daily for over a year and my skin has never looked to smooth. It has helped my fine lines so much that they are barely visible
I have suffered from all forms of rosacea and have improved dramatically since using this and
I have suffered from all forms of rosacea and have improved dramatically since using this and other clean and simple GOW products. I feel that the manuka honey serum is an essential base to the layering of serums I do.
Thank you so much, Catherine! 🌸Hearing that your skin has improved so dramatically is fantastic to hear!
We love that the Manuka Honey HA Serum has become the essential first layer in your routine, especially alongside your other GoW favorites!
Wishing you the best on this road to skincare health and happiness.
Markey and Your GoW Crew °❀⋆.ೃ࿔*:・°❀⋆.ೃ࿔*:・
It's really hard to find a fungal acne-safe body lotion! This lotion is light, and it's not instantly transformative, but over the past month or so I think it has helped the dry patches on my elbows and knees. I wish it was a tad richer, but I don't know if that's possible while also keeping it FA-safe. So I'll probably keep it in my routine!
Thank you for such a thoughtful and detailed review, Caroline! -`♡´- We’re glad you’re beginning to see improvement in those stubborn dry areas. We also truly appreciate your feedback about wanting a little more richness while keeping the formula fungal acne-friendly. That balance can be tricky, but your input is incredibly helpful to us!
Markey 🏵️🏵️🏵️
Absolute best thing for my white dry flyaway hair. 1/2 tsp MCT Oil heated with 1/4 tsp Cetyl Alcohol in a baby food jar in water in a leg wax warmer. When melted I add 1 tsp Distilled Water. I let cool in the warmer & apply to hair.
Hi Laura ♡♡♡
This is so interesting and clever! We love hearing how our customers put their ingredients to work! Knowing the Cetyl Alcohol has been the answer for smoothing and softening your dry, flyaway hair is inspiring. Keep up with the great ideas. Since your mixture contains water, we recommend making only a tiny amount at a time and using it fresh.
*Your GoW Crew ᵗᑋᵃᐢᵏ ᵞᵒᵘ ♡
This is my all time favorite body oil. Feels very luxurious.
Thank you so much! Our Bakuchiol Body Bliss Body Oil ... “Luxurious” is exactly how we want your skin to feel. We’re thrilled it has become such a favorite!
Markey 🌸🌸🌸
this seems like a very good product, but may be wrong for my skin type. i have rosacea and eczema, and mostly oily skin. i was hoping to find a product that would improve my heavily congested nose and chin without making all the red patches on my cheeks and eye area worse. i tried the product as both a toner and a facial spray, but found it slowly dried out my cheeks and made them redder. so now am am just applying only to my nose and cheeks, and it seems to be helping now, in conjunction with the oat serum. the product has the consistency of a typical toner, and it is scentless. it does not sting or burn when sprayed on, even in the eye area. it feels neither drying nor hydrating, and does not leave you looking greasy.
Hi Donna ♡
Thank you for sharing your experience with our Wild Black Cherry Bark Hydrosol. I'm glad to hear it's helping when used selectively.
We appreciate your detailed feedback and hope it continues to support your skin needs.
Feel free to reach out if you have any questions or need further assistance!
Thought: you could add about 2-3% glycerin to amp up the hydration.
Markey and the GoW Crew (✿◠ᴗ◠)