In "in vitro" human skin cultures, topical application of N-acetyl glucosamine and niacinamide stimulated hyaluronan synthesis. These treatments also led to an increase in collagen (procollagen-1) expression. Twice daily use of a facial moisturizer containing a combination of N-acetyl glucosamine and niacinamide for 4 to 8 weeks by women with moderate to severe fine and wrinkles reduced the appearance of facial fine lines and wrinkles, particularly in the eye area of the face. The in vitro hyaluronan results suggest that this effacement of fine lines and wrinkles is due at least in part to improved hydration of the skin. There are specific percentages in the actives used although this is considered proprietary information.
References 1.Sayo T, Sakai S, Inoue S. Synergistic effect of N-acetylglucosamine and retinoids on hyaluronan production in human keratinocytes. Skin Pharmacol Physiol 2004; 17: 77-83. 2.Ghersetich I, Lotti T, Campanile G et al. Hyaluronic acid in cutaneous aging. Int J Dermatol 1994; 33: 119-22. 3.Weindl G, Schaller M, Schafer-Korting M, Korting HC. Hyaluronic acid in the treatment and prevention of skin diseases: molecular, biological, pharmaceutical and clinical aspects. Skin Pharmacol Physiol 2004; 17: 207-13.
Method of Application Apply a pea-sized amount of this serum to your face and neck. Spritzing your face with spring water or a hydrosol will help this serum to glide across the skin gently yet effectively.
Shelf Life and Storage Information for Products and Ingredients
Finished Products generally don't need to be refrigerated as they are preserved, but you can refrigerate them to extend their shelf life. The shelf life for most products is 9-12 months. Vitamin C Serum(s) and VitaResurface products should always be refrigerated to extend their shelf life.
Sample Sizes do have a shorter shelf life (generally 3-6 months) and items in jars can dry up quicker than this if the lid is not tightened well enough (except our Vitamin C Serums - use within 90 days).
Please keep your products out of high humidity, heat, and direct light, and keep them in a dark cabinet when possible.
Exfoliating Acid products have a shelf life of 9-12 months. The only things we don't suggest refrigerating are the Mandelic Acid Serums or the Salicylic Acid Serums as those can crystallize in the refrigerator. If this happens you can set the product into a hot water bath to see if the crystals will dissolve.
Additional Items Requiring Refrigeration and/or Kept in the Dark
Hydrosols - remove 1 ounce of hydrosol and add it into a separate, sterilized spray bottle and spritzer. Keep the larger bottle in the refrigerator. Carrier Oils - generally you can refrigerate all carrier oils although some of the very rich oils will solidify. This is fine. All you have to do is take it out, warm it up at room temperature and it should liquefy. If not, setting the bottle in a hot water bath and occasionally shaking the bottle will hopefully turn into a liquid. ^There are some oils that have a super long shelf life like Coconut Cream and Jojoba Oil. Refrigeration is not necessary, but it surely won't hurt. Essential Oils - essential oils are best stored in a cool dark place. Co2 Extracts - these should always be refrigerated. Butters - we suggest refrigerating our "skincare' butters. You can take out what you need and keep the rest in the fridge. Clays - keep in a dry, dark place. Shelf life is at least 2 years. Herbs - all herbs (whole or ground) should be kept in a dark, cool and dry location. Herbal (liquid) Extracts - these are created using alcohol. The alcohol pulls the constituents from each herb. Root, Trunk, Leaves, and Flowers. Extracts have a shelf life of 3-5 years. They can be kept in the refrigerator (or a dark DRY place) Other Various Raw Ingredients - i.e. Sodium PCA, Honeyquat, Oat Beta Glucan, etc. will all have a different shelf life.
N-Acetyl Glucosamine glucose based monosaccharide, anti-inflammatory, antioxidant, naturally increases natural production of hyaluronic acid, promising evidence showing this helps to fight hyperpigmentation
Cosmocil CQ (Polyaminopropyl Biguanide) preservative that does not contains parabens or formaldehyde releasers
