Sometimes your skin is not dry, not oily, not even reactive... it is simply overwhelmed. It stops responding the way it used to. It looks a little more tired, a little less even, a little harder to settle. This is where Revitalize Your Skin Serum with Neurophroline™ begins.
This silky, lightweight serum was created for skin that is carrying the effects of daily stress. Not to force change, but to gently support a calmer, more balanced appearance. Skin is left looking more even, more rested, and more at ease.
At the center of this formula is Neurophroline™, a wild indigo seed extract chosen specifically for its ability to help reduce the visible effects of stress on the skin by reducing cortisol production locally in the skin cell. Rather than pushing the skin harder, it works in a quieter way, supporting a more refreshed, balanced complexion over time.
We paired it with Oat Beta Glucan, Thermo-stressine, Superoxide Dismutase, and other carefully chosen ingredients that help comfort the skin and defend against visible environmental strain.
This is not about pushing the skin harder. It is about helping it find its way back to balance.
Key Benefits
➜ Helps reduce the visible effects of daily skin stress
➜ Supports a calmer, more balanced-looking complexion
➜ Helps improve the appearance of uneven tone and fatigue
➜ Lightweight hydration without heaviness or buildup
➜ Supports skin exposed to environmental and emotional stress
Why It Feels Different
When skin is under ongoing stress, it does not always react loudly. Instead, it can begin to look duller, feel less comfortable, or lose some of its natural balance. This formula was designed with that in mind.
Neurophroline™ helps target the visible effects of stress on the skin, while Oat Beta Glucan helps soothe and support the skin barrier. Thermo-stressine helps support skin exposed to changing environmental conditions, and Superoxide Dismutase offers antioxidant support to help defend against visible oxidative stress.
Together, these ingredients create a serum that feels light, calm, and supportive, especially for skin that needs less pressure and more consistency.
Method of Application
Apply a small amount to clean skin after your water-based layers and before heavier serums, oils, or creams. Gently smooth over the face, focusing on areas that appear tired, uneven, or stress-worn. Use morning, evening, or both.
Featured Ingredients
➜Neurophroline™ – is a wild indigo seed extract that helps stressed skin calm down. Skin cells can produce cortisol locally in response to stress, and when cortisol stays elevated it can show up as redness, dullness, dehydration, and a more reactive barrier. Neurophroline is designed to help reduce cortisol production in skin cells while also encouraging the release of a calming neuropeptide (beta-endorphin), which supports a more balanced, refreshed-looking complexion over time.
➜Oat Beta Glucan – Helps soothe and support the skin barrier, contributing to a calmer feel.
➜Thermo-stressine – Helps support skin exposed to environmental stress and fluctuating conditions.
➜Superoxide Dismutase (S.O.D.) – An antioxidant enzyme that helps defend against visible oxidative stress.
Technical Notes
Neurophroline™ is derived from Wild Indigo (Tephrosia purpurea). This specialized extract contains naturally occurring sugars, including stachyose and ciceritol, and has been studied for its ability to help visibly improve skin tone and reduce the appearance of stress-related skin fatigue.
Shelf Life and Storage Information for Our Products and Ingredients
Finished Products - generally don't need to be refrigerated as they are preserved, but you can refrigerate them to extend their shelf life. The shelf life for most products is 9-12 months. Vitamin C Serum(s) and VitaResurface products should continually be refrigerated to extend their shelf life. Sample Sizes - do have a shorter shelf life (generally 3-6 months), and items in jars can dry up quicker than this if the lid is not tightened well enough (Vitamin C Serums - use within 90 days).
Please Keep Your Products Out of Humidity, Heat, Direct Light and in a Dark Cabinet When Possible
Exfoliating Acid - products have a shelf life of 9-12 months. The only things we don't suggest refrigerating are the Mandelic Acid Serums or Salicylic Acid Serums, as they can crystallize in the refrigerator. If this happens, you can set the product into a hot water bath to see if the crystals will dissolve.
Additional Items That Require Refrigeration and/or Kept in the Dark
Hydrosols and Distillates - remove 1 ounce of hydrosol and add it to a separate, sterilized spray bottle and spritzer. Keep the larger bottle in the refrigerator. Carrier and Exotic Oils - generally refrigerate all carrier oils, although some very rich oils will solidify. This is fine. All you have to do is take the oil out, warm it up at room temperature, and it should liquefy. If not, set the bottle in a hot water bath and occasionally shake the bottle, which will hopefully turn into a liquid. Some oils, like coconut cream and jojoba oil, have a super long shelf life.
Refrigeration of The Following Ingredients is Not Necessary, But it Won't hurt
Essential Oils - essential oils are best stored in a cool, dark place. Co2 Extracts - these should continually be refrigerated. Butters - we suggest refrigerating our "skincare" butters. You can remove what you need and keep the rest in the fridge. Clays - keep in a dry, dark place. Shelf life is at least 2 years. Herbs All herbs <i>(whole or ground)</i> should be kept in a dark, cool, and dry location. Herbal (liquid) Extracts are created using grain alcohol. The alcohol pulls the constituents (properties) from each herb, root, trunk, leaf, and flower. They have a shelf life of 3-5 years. They can be stored in the refrigerator or a dark, dry place. Other Raw Ingredients - such as Sodium PCA, Honeyquat, Oat Beta Glucan, etc., will all have different shelf lives.
Spring Water hydrating and helps prepare the skin to accept active ingredients Liposomes (phospholipids) penetration enhancer and extremely hydrating Leucidal SF (Lactobacillis Ferment) gentle preservative without parabens or formaldehyde releasers Neurophroline this exclusive extract has demonstrated its unique biological capabilities to break down the cortisol production by skin cells, activate the release of a natural calming neuropeptide acting to reduce redness, and enhance the overall appearance of the skin. Thermostressine® (tetrapeptide)this tetrapeptide increases the skin's tolerance to jet-lag and other daily lifestyle stresses. The proteotoxic stress is well controlled and damage prevented. Oat Beta Glucans are being studied for their potential immunomodulatory effects, anti-tumor properties, and stimulation of collagen deposition. Oat Beta Glucans have amazing healing properties.
Hyaluronic Acid (high molecular weight)Hyaluronic acid is a natural polysaccharide (large sugar molecule) that occurs in various tissues (skin, synovial fluids of joints, connective tissues).
Hyaluronic Acid(super low molecular weight)hyaluronic acid (sodium hyaluronate) is a natural polysaccharide (sugar) that occurs in body tissues including the skin providing hydration, stability, lubrication. This super low-molecular-weight form is made by enzymatically cleaving high-molecular weight hyaluronic acid into small fragments.
Dehydroxanthan Gumis obtained from fermented polysaccharides.This ia natural thickener. AllTrans ResveratrolAllTrans-resveratrol is a naturally occurring compound in certain plants, particularly grapes and red wine. It has been of interest in skincare and cosmetics due to its potential antioxidant and anti-aging properties. When applied topically to the skin, trans-resveratrol can exhibit several beneficial properties like antioxidant protection, anti-inflammatory, skin brightening, UV protection, collagen production and really keeps the skin hydrated. Apple Polyphenols are natural compounds found in apples, particularly in the skin and seeds of the fruit. They are a type of phytochemical, which means they are plant derived. Apple polyphenols, when used in topical applications, offer antioxidants, UV Protection, anti-inflammatory effects, they improve skin hydration while boosting collagen production. Yes, they are this good. Sclerotium Gum is a naturally derived, gel-like polysaccharide (sugar-based) thickener. Super Oxide Dismutase (S.O.D.) the highly purified superoxide dismutase made from Saccharomyces cerevisiae for skin care products. Offering anti-aging and skin-whitening properties while providing potent antioxidant effects inhibiting free radical formation.
This serum is a lovely tool in fighting signs of aging cause by lifes little stressors :)
Thank you, Erika.
You are adorable. We are always happy to hear when a product shows the results
one is hoping for.
Thank you for the video!
Markey ˚⊱⊰˚
A
Anonymous
Love it!
I love this product & so does my skin! For me, that is a huge blessing.
Hi Elayne!
Thank you for mentioning this product. It doesn't get enough ❤️.
Wishing you the best, as always, with your skincare journey.
Markey and Your GoW Crew of Lovlies.
˖˳·˖ ִֶָ ⋆͙⋆ ִֶָ˖·˳˖ ִֶָ
R
Rachel
Staple!!
Love love all GoW products I've tried, but this one was particularly interesting because of the Cortisol component! My skin has been a challenge the last 10 years and a lot of that was likely due to stress and hormones. In the last few years, things seemed to have leveled out but I still need support of course. I really do believe in a week or so I saw results from this serum. My skin is happy and hydrated! About to reorder my 2nd bottle :)
This is such a thoughtful review, and we're SOO happy for your results! Thank you so much :)
F
Frances S
Amazing product
I used this serum for the first time this week and I swear my skin immediately felt immediate relief. My skin actually feels satiated when I apply the serum. It is more even and glowing. I’m obsessed and hope this product is restocked asap. Thank you garden of wisdom!!!
Frances! I couldn't agree more! We tested this for awhile before releasing it and this product really is a game changer especially for those of us who find it more challenging to keep our skin hydrated and beautiful.
Thank you for the wonderful review, we always appreciate reviews.
Markey :-D
I love this serum so much. I have sensitive skin, and use this once a week so it lasts a while, and it makes such a big difference. Smooths lines, cleans pores, and evens skin tone.
Mandelic Acid 5% Serum
Kim
Unclogs pores and smooths bumps
This product has unclogged my pores and smoothed the bumps on my cheeks. I have very sensitive skin and this did not irritate my face. It does not work overnight, you need to stick with it for a while but it worked for me!
Azelaic Acid 8% Serum
Kim
My skin's texture and firmness have improved
I have noticed that my skin's texture and firmness have improved since I have been using this product. The fine lines seem a little smoother and it does not irritate my skin.
Eternal Youth Elixir - Rejuvenation Formula
Natali Hartley
Perfection :)
Love this product!! Especially during summer my skin just thrives with this! Not too thick or rich but leaves my skin happy and moisturized.
Wickedly Rich McDreamy Cream
Magdalena Manion
Work horse in my skin care routine
Work horse in my skin care routine. Have used for years. I spray a few sprays after cleansing on my face, neck, and chest, then use the extra moisture it provides to spread my serum. Resets the ph of my skin, makes everything feel more comfortable, and cost effective. Love it.
Clarifying Tonic
Anonymous
Tremendous product
Tremendous product. Only thing that consistently keeps my skin clear.
Blemish Prone Cleansing Oil
Caroline M.
Feels great on the skin
Feels great on the skin. I use it after cleansing but before serums, and it feels much more useful than a mineral water spray. I also like that it can be used throughout the day for a little boost. I had it in my purse last time I took a flight and I think it helped my skin stay happy during the journey.
Calm and Hydrate Mist
Lisa S
I recommend it to everyone!
I love this schampoo!! I was a little skeptical if an all natural shampoo would work, especially since I have fine, straight hair that tends to get greasy after only a couple of days with regular high quality shampoos, but this really works. I can go for 3 full days without washing it and I immediately noticed how powder soft my hair felt after the first wash. I think it even washes out the hard water. I will definitely be buying this again!
Locks of Lovely Shampoo (Unscented): Pure, Nourishing, and Gentle Care for Your Hair
Anonymous
Interesting new product
Interesting new product. I prefer the beautiful eye serum but this has some great ingredients
Blue Lotus Veil Peptide Infusion: Eye & Facial Renewal Serum
Teal Schinkel
ONLY MOISTURIZER THAT DOESNT CAUSE ACNE
Literally the only one I've ever used and I've searched for 30 yrs. Just the best!
I love this serum so much. I have sensitive skin, and use this once a week so it lasts a while, and it makes such a big difference. Smooths lines, cleans pores, and evens skin tone.
Hi Matt,
⋆.˚✮ ✮˚.⋆ for your kind review!
We're so happy to hear the serum is working well for your sensitive skin and that a little goes a long way. Hearing that you've noticed smoother-looking skin and a more even complexion makes us smile. ✌︎㋡
Thank you for being part of the GoW Family!
Your GoW Family
This product has unclogged my pores and smoothed the bumps on my cheeks. I have very sensitive skin and this did not irritate my face. It does not work overnight, you need to stick with it for a while but it worked for me!
Kim
Thank you so much for sharing your experience with our Azelaic Acid 8% Serum!
We especially appreciate that you mentioned both the results and the patience it took to get there. Skincare can sometimes be a journey rather than an overnight transformation, and feedback like yours helps set realistic expectations for others considering this or any product.
We're delighted to hear that it helped unclog pores and smooth the bumps on your cheeks while still being gentle enough for your sensitive skin. Finding that balance between effectiveness and comfort is always something we strive for when formulating.
Thank you for taking the time to leave a review and for allowing us to be part of your skincare routine. We love hearing success stories like yours! 😊
I have noticed that my skin's texture and firmness have improved since I have been using this product. The fine lines seem a little smoother and it does not irritate my skin.
Hi Kim,
Thank you! for sharing your experience!
We're so happy to hear you've noticed improvements in your skin's texture and firmness, and that the formula has been gentle on your skin. Hearing that your fine lines appear smoother makes us smile. 😊
Thank you for choosing Garden of Wisdom and for taking the time to leave a review!
Your GoW Family
Love this. So simple but effective. I use it daily on my face as it soothes my sensitive skin. Whenever anyone in our family has had too much sun or a sunburn, we use this - it's incredibly soothing and hydrating. Even my picky kiddos happily put it on sun-parched skin.
😁
Thankyou ❤️ so much for your wonderful review!
We love hearing that our Aloe Vera Inner Fillet Gel has become a family favorite. There's something special about a simple ingredient that does its job so well, and we're delighted that it's helping soothe both sensitive skin and sun-parched skin alike.
The fact that even your picky kiddos are happy to use it made us smile! 😊
Thank you for sharing your experience and for being part of our family and for so long too!
Your GoW Family
Love this product!! Especially during summer my skin just thrives with this! Not too thick or rich but leaves my skin happy and moisturized.
Hi Natali,
Thank you so much for your kind review! 😘
We're delighted to hear that Wickedly Rich McDreamy Cream is keeping your skin happy, especially during the summer months. Finding that sweet spot between nourishing and comfortable is exactly what we hoped for when creating it.
Thank you for taking the time to share your experience!
Your GoW Family