Targeted peptides and conditioning support for smoother, firmer-looking skin.

Our original Progeline™ Peptide Repair Serum pairs two targeted peptides with Hydrolyzed Elastin to help skin look smoother and firmer. Wild Yam Root Extract, oat beta-glucan, and antioxidants round out the formula with conditioning and comforting support.

Why You’ll Love It

A serum should feel lovely to use, too. This rich formula has a smooth, gliding feel that makes application a pleasure. It brings peptide support and skin-conditioning ingredients together for skin showing fine lines, a loss of firmness, or a less supple feel.

Key Benefits

➤ Helps skin look smoother and firmer

➤ Helps soften the appearance of fine lines

➤ Conditions skin for a softer, more supple feel

➤ Includes resveratrol and Superoxide Dismutase for antioxidant support

➤ Offers a rich, smooth glide during application

Why It Works

We brought these ingredients together because smoother-looking skin and comfortable-feeling skin belong in the same formula. The peptides focus on the appearance of firmness and fine lines. Hydrolyzed Elastin, Wild Yam Root Extract, and oat beta-glucan provide conditioning support, while resveratrol and Superoxide Dismutase contribute antioxidant activity.

Featured Ingredients

Progeline™ (Trifluoroacetyl Tripeptide-2)
A peptide selected to help improve the appearance of firmness and elasticity.

Syn-Coll (Palmitoyl Tripeptide-5)
A complementary peptide selected to help skin look smoother and firmer.

Hydrolyzed Elastin
A skin-conditioning protein that helps skin feel soft, smooth, and supple.

Wild Yam Root Extract
A botanical extract we include for its skin-conditioning qualities.

Oat Beta-Glucan
Helps comfort and condition the skin.

Resveratrol and Superoxide Dismutase
Antioxidants that complement the formula’s peptide and conditioning ingredients.

Texture & Feel

A rich serum with a smooth, gliding feel that spreads easily over the skin.

Best For

➤ Skin showing fine lines or a loss of firmness

➤ Skin that feels less soft or supple

➤ Those who enjoy a rich serum with a smooth glide

How to Use

1. Apply a few drops to clean skin.

2. Gently smooth or pat over the face, neck, and décolleté.

3. Follow with your preferred moisturizer or facial oil as needed.

4. Use morning and/or evening.

Good to Know

This is our original formula and contains animal-derived Hydrolyzed Elastin.

Prefer our vegetarian option? Explore our Progeline™ Peptide Repair Serum with Hydrolyzed Rice Protein, which replaces the Hydrolyzed Elastin.

Patch test before first use. Discontinue use if irritation occurs.

A Quiet Note from the Garden

We like a formula where each ingredient has a reason to be there. Here, we’ve paired targeted peptides with conditioning ingredients for a serum that feels lovely while supporting smoother-looking skin. Give it a consistent place in your routine, and remember that results vary from person to person.

Customer Reviews

Based on 12 reviews Write a review

Shelf Life and Storage Information for Our Products and Ingredients

Finished Products - generally don't need to be refrigerated as they are preserved, but you can refrigerate them to extend their shelf life. The shelf life for most products is 9-12 months. Vitamin C Serum(s) and VitaResurface products should continually be refrigerated to extend their shelf life.
Sample Sizes - do have a shorter shelf life (generally 3-6 months), and items in jars can dry up quicker than this if the lid is not tightened well enough (Vitamin C Serums - use within 90 days).

Please Keep Your Products Out of Humidity, Heat, Direct Light and in a Dark Cabinet When Possible 

Exfoliating Acid - products have a shelf life of 9-12 months. The only things we don't suggest refrigerating are the Mandelic Acid Serums or Salicylic Acid Serums, as they can crystallize in the refrigerator. If this happens, you can set the product into a hot water bath to see if the crystals will dissolve.

Additional Items That Require Refrigeration and/or Kept in the Dark

Hydrosols and Distillates - remove 1 ounce of hydrosol and add it to a separate, sterilized spray bottle and spritzer. Keep the larger bottle in the refrigerator.
Carrier and Exotic Oils - generally refrigerate all carrier oils, although some very rich oils will solidify. This is fine. All you have to do is take the oil out, warm it up at room temperature, and it should liquefy. If not, set the bottle in a hot water bath and occasionally shake the bottle, which will hopefully turn into a liquid. Some oils, like coconut cream and jojoba oil, have a super long shelf life.    

Refrigeration of The Following Ingredients is Not Necessary, But it Won't hurt

Essential Oils - essential oils are best stored in a cool, dark place.   
Co2 Extracts - these should continually be refrigerated.
Butters - we suggest refrigerating our "skincare" butters. You can remove
what you need and keep the rest in the fridge.
Clays - keep in a dry, dark place. Shelf life is at least 2 years.
Herbs All herbs <i>(whole or ground)</i> should be kept in a dark, cool, and dry location.
Herbal (liquid) Extracts are created using grain alcohol. The alcohol pulls the constituents (properties) from each herb, root, trunk, leaf, and flower. They have a shelf life of 3-5 years.
They can be stored in the refrigerator or a dark, dry place.
Other Raw Ingredients - such as Sodium PCA, Honeyquat, Oat Beta Glucan, etc., will all have different shelf lives.

Shipping Transit Note:
Some customers have asked whether products can be affected by time in transit, especially during warmer months. Our products are formulated and preserved to remain stable during normal shipping times and should not spoil simply from being in transit.

That said, if you are concerned about heat exposure, you are welcome to add an ice pack to your order for extra peace of mind. Click here to add an ice pack.

Ingredient Transparency

We want you to understand what goes into your serum and why we include it. Each ingredient below is paired with its INCI, the standardized ingredient name used on cosmetic labels. The complete ingredient list is available in the separate INCI tab.

Glacial Water | INCI: Aqua (Water)
The water base of our formula, helping dissolve and distribute its water-soluble ingredients.

Wild Yam Root Extract | INCI: Dioscorea Villosa (Wild Yam) Root Extract
A botanical extract we include for its skin-conditioning qualities.

Hydrolyzed Elastin | INCI: Hydrolyzed Elastin
An animal-derived protein that helps condition the skin for a soft, smooth, and supple feel.

Oat Beta-Glucan | INCI: Beta-Glucan
Selected to help comfort and condition the skin, complementing the formula’s targeted peptides.

Progeline™ | INCI: Glycerin, Aqua (Water), Dextran, Trifluoroacetyl Tripeptide-2
A peptide blend selected to help improve the appearance of firmness and elasticity.

Syn-Coll | INCI: Glycerin, Aqua (Water), Palmitoyl Tripeptide-5
A complementary peptide blend selected to help skin look smoother and firmer.

Leucidal® SF | INCI: Lactobacillus Ferment
A fermentation-derived ingredient used as part of the formula’s preservation system.

Resveratrol | INCI: Resveratrol
An antioxidant included to complement the formula’s peptide and conditioning ingredients.

Superoxide Dismutase | INCI: Superoxide Dismutase
An antioxidant enzyme that rounds out the formula’s antioxidant support.

What Does INCI Mean?

INCI stands for International Nomenclature of Cosmetic Ingredients. These standardized names help you identify the ingredients in your skincare.

For an explanation of each ingredient and why we include it, visit the Ingredient Transparency tab.

Ingredients (INCI)

Aqua (Water), Dioscorea Villosa (Wild Yam) Root Extract, Hydrolyzed Elastin, Beta-Glucan, Glycerin (and) Aqua (Water) (and) Dextran (and) Trifluoroacetyl Tripeptide-2, Glycerin (and) Aqua (Water) (and) Palmitoyl Tripeptide-5, Lactobacillus Ferment, Resveratrol, Superoxide Dismutase.

Progeline™ Peptide Repair Face Serum

Customer Reviews

Based on 31 reviews
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Karen Nagamoto

So far my skin likes this after spritzing with hydrosol. Then I mix a little with sweet almond oil to help seal it in. It doesn't clog my pores or make me break out like other products. Thank you!

Hi Karen, thank you for sharing your experience.
We're so grateful you shared your experience that the Progeline™ Peptide Repair Serum works well with your skincare routine.
Your feedback is greatly appreciated!
Wishing you the very best in your skincare journey,
Markey & Your GoW Crew ִֶָ ࣪ ִֶָ་༘࿐

a
anne marie waldron
no change

no change whatsoever

Anne Marie 🌞
We are genuinely sorry you didn't see the changes you were hoping for. Skincare results can vary widely from person to person, but we never want anyone to feel disappointed after choosing one of our products. We'll reach out privately to learn more about your experience and see how we can help.
Markey
Owner/Founder
Garden of Wisdom

T
TONI B.
Awesome progeline peptide repair serum

I have this product daily for over a year and my skin has never looked to smooth. It has helped my fine lines so much that they are barely visible

A full year of daily use gives you a wonderful perspective on how a formula truly performs, Toni. (❀❛ ֊ ❛„)♡
Peptide serums are all about consistency, so we love hearing how much smoother your skin looks and how dramatically the appearance of your fine lines has softened. Thank you for staying with our Progeline™ Peptide Repair Serum and sharing your results!
This is exciting news!
Markey ❤️❤️❤️

L
Lyn
VISIBLE EFFECTS IN AGING SKIN

This product has made the most difference to fine lines and wrinkles of any one product I use, especially in DEEP FROWN LINES IN LOWER FACE - and I use a lot of serums! It is definitely worth the price - the most I've ever spent on any skincare product. After trying the small-sized bottle, I purchased the 4 oz bottle at regular price and bought another bottle two weeks later during GOW's spring sale!

Lyn ... Thank you!
This means so much… truly ❤️
Hearing that it’s making a visible difference, especially in deeper lines, is something we never take lightly. And the fact that you came back for the larger size, and then again during the sale… that kind of trust means everything to us.
Thank you for sharing this so thoughtfully.
Markey, Jen, and our amazing team ͙֒

K
Kimberly Dognaux
ProgelinePeptide Repair Serum

So far, good!! The serum goes on smoothly and soaks into my skin. This will be a nice addition to my skin care routine.

Kimberly
Thank you for the kind review. This has been a popular product for so many years; it's crazy.
You defined it perfectly; as it goes on smoothly and soaks right in. Well done!
Your Gow Team