Viper Venom Serum 5%


SKU: AA-32

Synake (Viper Venom as we like to call it) is a new anti-wrinkle active compound based on a synthetic tripeptide that mimics the affect of Waglerin 1, a peptide that is found in the venom of the Temple Viper, Tropidolaemus wagleri. Used for its excellent anti-wrinkle active compound which smoothes mimic wrinkles in a short period of time.

NOTE: this serum will give an immediate Botox-like effect but it is also cumulative. Give it 30 days for the full effect. This product should be used ONLY for spot treatments, i.e. laughs lines, forehead, neck, crow's feet, etc 

Method of Application

Our Viper Venom Serum is meant to be applied twice daily, not to the wrinkle or line itself, instead to the muscles that make the wrinkles. (Please see the Facial Chart below for reference) You can also make faces in the mirror to see where the muscles are. It’s fun and you'll learn something at the same time. ;)
Directions: Apply 1 -2 drops to the muscle area that creates the wrinkle or line that you would like to eliminate.

List of Ingredients

Hyaluronic Acid hydrating, can hold up to 1,000 times it's weight in water
Syn®-Ake 5%

SYN®-AKE – Age Killing Effect.
  •   Antagonist of the muscle nicotinic acetylcholine receptor
  •   Blocks Na+ uptake at the post-synaptic membrane
  •   Inhibits muscle contractions
SYN®-AKE is a new anti-wrinkle active compound based on a synthetic tripeptide that mimics the effect of Waglerin 1, a peptide that is found in the venom of the Temple Viper, Tropidolaemus wagleri. PENTAPHARM *(Syn-ake's manufacturer) has developed, over the past 30 years, a unique approach for the breeding and housing of venomous snakes and particularly the Brazilian Lance Adder Bothrops moojeni whose venom is used for therapeutic (anticoagulants, haemostatics) and diagnostic products. Currently, some 10, 000 specimens of this snake species are bred and housed at PENTAPHARM DO BRASIL, making PENTAPHARM the largest snake breeder and keeper in the world. The long experience of PENTAPHARM in snake venom research has made possible the investigation of venom’ peptides for cosmetic applications. A special focus has been the investigation of the Temple Viper’s venom. 

SYN®-AKE acts in a manner similar to that of Waglerin 1 which acts at the post-synaptic membrane. The peptide is an antagonist of the muscular nicotinic acetylcholine membrane’s receptor (mnAChR). As the muscular nicotinic ACh receptors are blocked, the ion canal remains closed. There is no uptake of Na+ and the muscles stay relaxed. Source: McArdle, JJ, T L Lentz, V Witzemann, H Schwarz, SA Weinstein& JJ Schmidt. 1999. Waglerin-1 selectively blocks the epsilon form of the muscle nicotinic acetylcholine receptor. J. Pharmacol. Exp. Therap.


• SYN®-AKE is an excellent anti-wrinkle active compound with a snake venom-like mode of activity.
• SYN®-AKE smoothes mimic wrinkles in a short period.
Cosmetic applications:
• Age killing effect particularly effective against expression lines
• Intensive anti-wrinkles care

INCI Name:

Glycerine, Water, Dipeptide Diaminobutyroyl Benzylamide Diacetate

Efficacy Tests- in vitro tests:
The efficacy of the SYN®-AKE tripeptide (at a concentration of 0.5mM) has been demonstrated in vitro by measuring the frequency of contraction of the innervated muscle cells as a function of the incubation time.

SYN®-AKE peptide reduces muscle cell contraction and its action is reversible.

In vivo tests:

The measurement of the smoothing and anti-wrinkle effect of SYN®-AKE (4%) was compared to a placebo.
A cream was applied to the forehead twice daily during 28 days.

SYN®-AKE – Age Killing Effect.

The smoothing effect (Ra) was measured on 80% of the volunteers and the anti-wrinkle effect (Rz, Rt) measured on 73% of the volunteers.

 Results showed up to -52% of wrinkle size after
28 days application!