Turn Back the Clock on Aging Unlock the secret to youthful, plump skin with Adipofill™ Natural Wrinkle Filler Serum – the Advanced Anti-Aging Solution to Achieve Youthful Skin. Specially designed to combat the three primary processes of facial aging - cellular, cutaneous, and structural, this innovative serum specifically targets structural aging, which leads to a decrease in adipose tissue and the visible loss of facial fullness.
As we age, our facial fat pads gradually diminish due to disruptions in adipocyte metabolism, leading to deep nasolabial folds, sagging jowls, and hollows under the eyes. Adipofill™ Natural Wrinkle Filler Serum mimics the rejuvenating effects of lipofilling, a procedure often used in plastic surgery, by activating hypoxia-inducible factor (HIF)-1-alpha, a critical transcription factor. This activation stimulates adipocyte anabolism and reduces fatty acid release, helping to visibly plump and firm the skin while significantly reducing nasogenian wrinkles for a naturally youthful appearance.
An Innovative, Non-Surgical Solution
Harnessing the lipo hormesis phenomenon, Adipofill™ Natural Wrinkle Filler Serum enhances HIF-1α gene expression and related genes associated with adipocyte growth. This leads to a non-invasive, bio-controlled rejuvenation of facial structure, delivering surgical-like results without the need for injections or incisions. Supported by clinical studies, this serum offers a breakthrough approach to age-related facial volume loss, making it a valuable addition to any advanced anti-aging regimen.
Key Ingredients for Total Skin Rejuvenation
Anemarrhena Asphodeloides Root Extract - Promotes skin plumping for a fuller appearance. Panthenol (Vitamin B5) - A deeply penetrating moisturizer that soothes, heals, and encourages cell regeneration. Glycoproteins - Boost oxygenation, energy levels, and hydration while aiding cellular repair. Adipofill™ (L-ornithine in liposomes) - Clinically proven at the manufacturer's highest recommended concentration to visibly fill and lift aging skin. Aspen Bark Extract - A natural exfoliant and antibacterial agent that preserves skin health. Astaxanthin - A potent antioxidant that combats oxidative stress and inflammation. Resveratrol - A powerful free radical fighter that supports overall skin vitality and longevity.
Experience Youthful, Plump Skin
Reclaim youthful vibrance with Adipofill™ Natural Wrinkle Filler Serum – the Advanced Anti-Aging Solution to Achieve Youthful Skin. Achieve firmer, smoother, and fuller skin without invasive procedures, only the pure power of science-driven skincare. Say goodbye to deep wrinkles and sagging skin and welcome the rebirth of your natural radiance!
NOTE: While this formula delivers outstanding results for many, a few customers have reported mild irritation, including a rash and tiny bumps. We recommend reviewing the full ingredient list to ensure compatibility with your skin profile before use.
Shelf Life and Storage Information for Our Products and Ingredients
Finished Products - generally don't need to be refrigerated as they are preserved, but you can refrigerate them to extend their shelf life. The shelf life for most products is 9-12 months. Vitamin C Serum(s) and VitaResurface products should continually be refrigerated to extend their shelf life. Sample Sizes - do have a shorter shelf life (generally 3-6 months), and items in jars can dry up quicker than this if the lid is not tightened well enough (Vitamin C Serums - use within 90 days).
Please Keep Your Products Out of Humidity, Heat, Direct Light and in a Dark Cabinet When Possible
Exfoliating Acid - products have a shelf life of 9-12 months. The only things we don't suggest refrigerating are the Mandelic Acid Serums or Salicylic Acid Serums, as they can crystallize in the refrigerator. If this happens, you can set the product into a hot water bath to see if the crystals will dissolve.
Additional Items That Require Refrigeration and/or Kept in the Dark
Hydrosols and Distillates - remove 1 ounce of hydrosol and add it to a separate, sterilized spray bottle and spritzer. Keep the larger bottle in the refrigerator. Carrier and Exotic Oils - generally refrigerate all carrier oils, although some very rich oils will solidify. This is fine. All you have to do is take the oil out, warm it up at room temperature, and it should liquefy. If not, set the bottle in a hot water bath and occasionally shake the bottle, which will hopefully turn into a liquid. Some oils, like coconut cream and jojoba oil, have a super long shelf life.
Refrigeration of The Following Ingredients is Not Necessary, But it Won't hurt
Essential Oils - essential oils are best stored in a cool, dark place. Co2 Extracts - these should continually be refrigerated. Butters - we suggest refrigerating our "skincare" butters. You can remove what you need and keep the rest in the fridge. Clays - keep in a dry, dark place. Shelf life is at least 2 years. Herbs All herbs <i>(whole or ground)</i> should be kept in a dark, cool, and dry location. Herbal (liquid) Extracts are created using grain alcohol. The alcohol pulls the constituents (properties) from each herb, root, trunk, leaf, and flower. They have a shelf life of 3-5 years. They can be stored in the refrigerator or a dark, dry place. Other Raw Ingredients - such as Sodium PCA, Honeyquat, Oat Beta Glucan, etc., will all have different shelf lives.
Spring Water - hydrating, natural solvent Anemarrhena Asphodeloides Root Extract - skin plumping Panthenol B-5 - penetrating moisturizer, soothing, healing, encourages cell regeneration Glycoproteins - aids in the cellular repair process, boosts the skin's oxygen content, increases the energy level of skin cells by enhancing the production of energy-rich adenosine triphosphate, high in polysaccharides which allows for extra hydration to the skin. Glycoproteins boost the skin's oxygen content, increase the cellular respiration capacity, and increase the energy level of skin cells by enhancing the production of energy-rich adenosine triphosphate (ATP). Glycoproteins also have moisturizing properties due to their content of water-binding polysaccharides. Adipofill™ - (we formulate with the strongest percentage recommended by the manufacturer) a patented L-ornithine amino acid encapsulated in an Ionosome. is thus an innovative, sophisticated, and high-tech ingredient that fights the aging process for a plump and youthful look. Aspen Bark Extract - preservative, gentle exfoliator, anti-bacterial Astaxanthin - naturally-occurring carotenoid found in algae, anti-oxidant, anti-inflammatory Resveratrol - functions (in plants) as a phytoalexin, a substance produced by plants that can inhibit the growth of infecting fungi or other pathogens. Resveratrol presents itself with antiviral, antioxidant, anti-inflammatory, and neuroprotective activities which fights the degradation of cell functioning to fight the free-radicals Xanthan Gum - natural thickener
I love popping this serum on to plump my fine lines
I love popping this serum on to plump my fine lines. It leaves my skin looking and feeling more supple :)
Erica, thank you for this review! Your attention to seeing the changes in your skin are greatly appreciated.
You are as well.
˖˳·˖ ִֶָ ⋆͙⋆ ִֶָ˖·˳˖ ִֶָ
C
Cynthia Nosewicz
Its helping.
So far it seems to be plumping deep wrinkles.
Cynthia
So far, it seems to be plumping deep wrinkles. - Adipofill™ Natural Wrinkle Filler Serum.
Please keep us updated here or privately if you wish.
Thank you!
V
Valerie
Great serum!
I have had great luck with Adipofil! It has definitely added volume to my face. I use this serum every evening. As we age, we noticeably lose volume in our face and I will use anything that might help to maintain it!
Thank you for the review, Valerie.
We know it takes time from your busy day to list reviews and yours are
dearly appreciated.
Your GOW team :-D
M
Mary Gleason
Love item
Only using for a short time so far but feel Im already noticing positive results and seem to notice less hollowing in areas of concern. Very pleased! Am gonna keep using. Great product!
Mary,
Thank you for this review! This is one product that will work given time depending on how long the customers have had to deal with the 'hollowing'.
It's always important that customers are able to read others results.
Again, thank you!
Markey
A
Anne
A great addition
I enjoyed using this product. It plumped out fine lines and added in other problem areas. I love trying things I don’t see in other skin care lines. Thanks gow for something new.
Love it for my neck. Will try on my face at some point. I have Rosacea so I have to be careful with my face. Love Bakuchiol for the body too.
Bakuchiol (Sytenol®A) Botanic Facial Oil Booster
Michelle Castro
Winter Skin MUST HAVE
I love the other GOW hydrating mists but has not tried this one yet. My skin is on the struggle bus this Fall. Due to weather plus perimenopause I felt like I couldn’t get enough hydration no matter what! Purchased the 1oz size of this mist to try and it’s a game changer!! I just ordered the 4oz size during a sale. Never want to be without this during Fall and Winter.
Customer Created Deep Hydrating Mist
Jamie Lyn Ross
Another WIN from Garden of Wisdom
I've never not loved Garden of Wisdom products 100%, and this is no exception... I alternate the C3 Elixir with other GoW products (the C3 does great on off-days that I don't use peptides), and it's been a great addition to my skin's arsenal. Some products can be drying or irritating to my skin but this isn't, at all!
I have to say... Markey and the entire team at Garden of Wisdom is a blessing. They do what they do out of a passion for helping people, and crafting high-quality, clean and safe products, at an affordable price - along with the utmost customer service (and I love the little hand-written notes I get with each order :)
Thank you, Markey, Leah, Jen, and the rest of your awesome team. xo
C³ Lipid Elixir
Erika Davies
I love popping this serum on to plump my fine lines
I love popping this serum on to plump my fine lines. It leaves my skin looking and feeling more supple :)
This Hair Oil is very nourishing and lightweight. I use it as a finishing touch to add shine and condition. Thank you!
Rockin Moroccan Goddess Hair Oil
Terri Froman
The Yarrow Blossom Healing Mist & Hydrating Mist is a staple in my daily upkeep!
I keep coming back to the Yarrow Blossom Healing mist. It's a staple!
Yarrow Blossom Healing and Hydrating Mist
Mike
Finally a Azelic acid product with the perfect ingredients
I have extremely reactive rosacea + POD + seb derm and have never been able to tolerate other azelaic products (Finacea, The Ordinary, Cos De Baha, etc.). They all left me flushed, burning, slick-oily and “raw” the next morning – even at low %.
Wisdom’s azelaic serum is the complete opposite. The base is incredibly gentle: no sting, no burn, no delayed flare. I can apply it at night after just a water rinse, my skin might flush for a minute (vascular rosacea doing its thing), then it calms right down. I wake up with skin that looks calm, not cooked – still a bit oily (normal for me), but far less than before and without that angry, inflamed look.
It’s the first azelaic that actually works with my barrier instead of fighting it. If you have super sensitive, rosacea-prone, seb-derm-ish skin and thought azelaic just “isn’t for you,” this formula is honestly worth a try.
Please can you consult with your customers if you ever want to discontinue this product? will happily stock up if that ever happens.
Azelaic Acid 8% Serum
Anonymous
FirmAge
Love this! Works for my skin & allergic reactions! 😊
FirmAge 5% DMAE Gel w/Lavender - Sagging Skin Support Tightening and Firming
Marie Donald
This cream is so healing to my skin
This cream is so healing to my skin. I have a sensitivity to citrus products and get a terrible rash and my face will itch. This is the only product that calms my skin.I apply this and within a few hours the rash has diminished and the itchiness is gone. The Calendula Blossom Cream has saved my skin.
Calendula Blossom Cream
Anonymous
Love it!
I love this product & so does my skin! For me, that is a huge blessing.
Where would I be without this serum? It keeps me clear and doesn’t cause any irritation to my eczema-prone skin. This is a must-have.
Jessica
Thank you for your positive feedback!
PS- your lead in line is fantastic We absolutely love to hear that the Salicylic Acid 2% Serum has been a game-changer for your skin. We always strive to provide effective and gentle products for our customers, and we're glad to know it has helped with your eczema.
Thank you for making us a must-have in your skincare routine!
Your GoW Team
Love it for my neck. Will try on my face at some point. I have Rosacea so I have to be careful with my face. Love Bakuchiol for the body too.
Hi Cynthia 😊
Thank you for taking the time give us a review.
It's so exciting to know the Bakuchiol p;roducts work so well with your sensitive, Rosacea skin profile.
Have a wonderful week.
Markey ❤️
I love the simplicity of this formula. This makes a great nourishing and healing serum. I have to be careful with hyaluronic acid (all molecular weights) and retinol/al(s), all which tend to dehydrate my skin. Oat beta glucans bring it back to life!
Alyssa
⋆.˚✮ ✮˚.⋆ for leaving a review for our Oat Beta Glucans. We use this ingredient in a lot of our formulas as it is extremely healing and soothing to the skin. Actually, years ago there was a customer who did a study on this ingredient and found so many favorable reviews and testimonials from people with extreme burns and it fascinated us. Kudos to the dear lady! We're so glad to hear that it has been nourishing and healing for your skin. It's great to know that it's a helpful alternative for those who may have sensitivities to other ingredients like hyaluronic acid and retinol.
We’re so grateful you took the time to write us.
Wishing your skin continued comfort and balance during this journey.♡
I love the other GOW hydrating mists but has not tried this one yet. My skin is on the struggle bus this Fall. Due to weather plus perimenopause I felt like I couldn’t get enough hydration no matter what! Purchased the 1oz size of this mist to try and it’s a game changer!! I just ordered the 4oz size during a sale. Never want to be without this during Fall and Winter.
Hi Michelle
Thank you for sharing your positive experience with our Deep Hydrating Mist! Your enthusiasm is so cool and we really appreciate it! One of our customers in the UK gave us the idea so all the credit truly goes to her. We're so happy to hear that it's been a game changer for your winter skin struggles.
We hope it continues to provide the hydration you need during this season.
Thank you for your continued support and we're glad you took advantage of our sale to stock up on the larger size.
Have a great day and a beautiful weekend.
I've never not loved Garden of Wisdom products 100%, and this is no exception... I alternate the C3 Elixir with other GoW products (the C3 does great on off-days that I don't use peptides), and it's been a great addition to my skin's arsenal. Some products can be drying or irritating to my skin but this isn't, at all!
I have to say... Markey and the entire team at Garden of Wisdom is a blessing. They do what they do out of a passion for helping people, and crafting high-quality, clean and safe products, at an affordable price - along with the utmost customer service (and I love the little hand-written notes I get with each order :)
Thank you, Markey, Leah, Jen, and the rest of your awesome team. xo
Jamie •ᴗ•
Thank you so much for sharing this. It means more than you know. We pour so much care into every formula, and hearing that the C³ Lipid Elixir is fitting so comfortably into your routine truly warms our hearts. We’re always mindful of creating products that feel gentle, effective, and trustworthy on the skin, and feedback like yours reminds our whole team why we do what we do.
Your kind words about our little notes and our customer service touched us deeply. From all of us here at Garden of Wisdom, thank you for being part of our community and for letting us support you on your skincare journey.
Your Team @ Garden of Wisdom